Cell proliferation in human coronary arteries
Authors:
Gordon, D.
Reidy, M.A.
Benditt, E.P.
Schwartz, S.M. (Univ. of Washington, Seattle (USA))
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| Abstract: Despite the lack of direct evidence for cell multiplication, proliferation of smooth muscle cells in human atherosclerotic lesions has been assumed to play a central role in ontogeny of the plaque.^The authors used antibodies to cell cycle-related proteins on tissue sections of human arteries and coronary atherosclerotic plaques.^Specific cell types were identified by immunochemical reagents for smooth muscle, monocyte-macrophages, and other blood cells.^Low rates of smooth muscle cell proliferation were observed.^Macrophages were also observed with rates of proliferation comparable to that of the smooth muscle.^Additional replicating cells could not be defined as belonging to specific cell types with the reagents used in this study.^These findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes. |
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| Publication Date: |
01 Jun 1990
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| Resource Type: |
Journal Article
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| Resource Relation: |
Proceedings of the National Academy of Sciences of the United States of America ; Vol/Issue: 87:12
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| Country of Publication: |
United States
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| Language: |
English
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